Common Types of Amyloidosis
Amyloidosis is a term designated for representing diseases that involve the abnormal protein amyloid. These diseases are different but all share the amyloid protein fibers that can develop in organs, tissue, nerves and other areas in the body. Diagnosing which specific disease is very important as treatments vary based on which. Amyloid originates from inside bone marrow and can be deposited in any organ or tissue. Symptoms may not be present until the disease has progressed into later stages and they vary based on which organs are affected. Symptoms include: • Fatigue and low-energy • Numbness, carpal tunnel syndrome • Ankle and leg swelling • Shortness of breath • Enlarged tongue • Diarrhea (sometimes with blood or constipation) • Unexpected weight loss • Difficulty swallowing • Skin bruising, purple around eyes • Irregular heartbeat There is no cure for any of these diseases, however the folloiwng types can be managed through proper treatment: 1. Light Chain AL Amyloidosis This is the most common type of amyloidosis and affects kidneys, nerves, heart, skin and liver. This takes place when bone marrow produces abnormal antibodies that are eventually deposited into tissue as amyloid. 2. Autoimmune AA Amyloidosis It generally targets the kidneys, but can also affect liver, digestive tract and heart.